EPA1 en. From the results shown in Table 5, a high-purity N by using as a starting material of high purity 1,3-diallyl hexahydropyrimidine by distillative purification in the second step B the third step BN '- diallyl-1,3-diaminopropane is obtained, it is clear that it is possible to further increase the purity thereof by performing a further distillation purification. Hereinafter, N of the present invention through examples thereof, N'- diallyl-1,3 manufacturing process of diaminopropane will be described in detail, the present invention is not intended to be limited by these. Ref document number : Country of ref document : JP. Process for preparation of optically active halogeno hydroxypropyl compound and glycidyl compound. In view of suppressing the formation of economics and by-products, it is more preferably kept to mol of acid with respect to 1,3-diallyl hexahydropyrimidine 1 mol. More specifically, after the addition of hydrophobic organic solvent to the reaction solution was basified by addition of base, further subjected to washing operation by adding water, an organic solvent by concentration under reduced pressure after removal of the base and water solvent the if distilled off, the crude N, can be obtained N'- diallyl-1,3-diaminopropane. A VWR representative will contact you if needed. GC retention time of N- allyl-1,3-diaminopropane in condition B was Micro Mass ZQ.
(S)()1,2Diaminopropane dihydrochloride, 99 Fisher Scientific
At last,(S)-(-)-1,2-Diaminopropane dihydrochloride() safety, risk, hazard and MSDS, CAS,cas number,Use,cas no may also be you need. Aldrich; (S)-(-)-1,2-Diaminopropane dihydrochloride ; CAS No.: ; Synonyms: (S)-(-)-Propylenediamine dihydrochloride; (S) Aldrich; (R)-(+)-1,2-Diaminopropane dihydrochloride ; CAS No.: ; Synonyms: (R)-(+)-Propylenediamine dihydrochloride; 1.
After the addition of allyl chloride biphasic reaction solution Incidentally, the end point determination of the reaction, for example, the generation of loss or hexahydropyrimidine of 1,3-diaminopropane which is the starting material gas chromatography hereinafter, "GC" may be carried out to check in. After drying the organic layer of the biphasic reaction solution was separated into an organic layer and aqueous layer with sodium hydroxide 8.
Chorus systems are reliable water purification units constructed from the highest quality components. The present inventors have conducted intensive studies in order to solve the above problems result, 1,3-diaminopropane and without purification hexahydropyrimidine obtained by reaction of formaldehyde, the allyl halide and a base successively N by reacting in the presence, N'- dialkylated reaction proceeds, a stable intermediate 1,3-diallyl hexahydropyrimidine has found that it is possible one-pot synthesis.
The amount of base used in the above second step A is preferably also in excess than the amount of the allyl halide used in the second step A.
(R)(+)1,2Diaminopropane dihydrochloride C3H12Cl2N2 PubChem
1,2-diaminopropane dihydrochloride, (R)-isomer. Structure, properties, spectra, suppliers and links for: 1,2-Propanediamine dihydrochloride.
It said second step includes a purification step of distilling purify the resulting 1,3-diallyl hexahydropyrimidine The method according to any one of claims 1 to 7.
In Table 1, the study of Entry4, showing a detailed procedure below. The third step in the scheme B B is, N 1,3-diallyl hexahydropyrimidine represented by Formula IIthe acidolysis reaction of N'- aminal site, represented by formula III N, to give compound N'- diallyl-1,3-diaminopropane.
Item s Added successfully! Specifically, the method of Non-Patent Document 1, 1,3-diaminopropane and the formaldehyde are reacted, N, N'Amina - is intended to synthesize hexahydropyrimidine by Le forming reaction, et al 2 method, non-patent document 1 way to adding a 2-hydroxybenzaldehyde are added, in which improvements to remove reaction by-products have been made.
1 2 diaminopropane dihydrochloride uses
|N in the above Step 3 Ain the acid degradation of N'- aminal site, procedure of dropping the acid with respect to 1,3-diallyl hexahydropyrimidine solution is preferred.
Incidentally, the addition of a large excess of base to the reaction solution, inorganic salts is precipitated by the reaction solution saturated, since there is a case where stirring becomes difficult, the amount of base relative to 1,3-diaminopropane 1 mole more preferably suppressed to 1 to 5 mol.
This product has been blocked by your organization. After the addition of allyl chloride biphasic reaction solution Processes for preparing intermediate compounds useful for the preparation of cinacalcet. The first and second steps of the present invention, i.
Video: 1 2 diaminopropane dihydrochloride uses Ethylenediamine
Molecular Formula: C₃H₁₀N₂ • 2(HCl). Molecular Weight: Applications: (S)-(-)-1,2-Diaminopropane Dihydrochloride is used in the synthesis of. (R)-(+)-1,2-Diaminopropane dihydrochloride/ACM can be provided in Alfa Chemistry.
1,2Propanediamine dihydrochloride C3H12Cl2N2 ChemSpider
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Crosslinked polyallylamine or acid addition salt thereof, and use thereof for medical purposes. N, GC purity N'- diallyl-1,3-diaminopropane is weighed a sample of about 20mg to 10mL volumetric flask, and those volume with distilled water GC measured under the above conditions B, calculated from Equation 4 did.
EPA1 en. Specifically disclosed is a method for producing N,N'-diallyl-1,3-diaminopropane or an acid addition salt thereof, comprising: a first step for reacting 1,3-diaminopropane with formaldehyde to give hexahydropyrimidine; a second step for reacting hexahydropyrimidine with an allyl halide in the presence of a base to give 1,3-diallylhexahydropyrimidine through an N,N'-dialkylation reaction; and a third step for decomposing the N,N'-aminal moiety of 1,3-diallylhexahydropyrimidine to give N,N'-diallyl-1,3-diaminopropane.
1,2Diaminopropane C3H10N2 PubChem
After the addition of allyl chloride biphasic reaction solution
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|The phase transfer catalyst mentioned above, for example, tetrabutylammonium bromide, tetrabutylammonium iodide, quaternary ammonium salts such as tetrabutyl ammonium sulfate, quaternary phosphonium salts such as tetrabutylphosphonium chloride, pyridinium compounds, such as dodecyl pyridinium chloride or crown but ether, preferably tetrabutyl ammonium bromide or tetrabutyl ammonium iodide, tetrabutyl ammonium bromide is more preferable.
The solvent used in the above third step Ais not particularly limited as long as it does not inhibit the reaction, for example, aliphatic alcohol-based organic solvent methanol, ethanol, 1-propanol, 2-propanol, etc. Reacting the 1,3-diaminopropane and formaldehyde, a first step of obtaining a hexahydropyrimidine, A hexahydropyrimidine and an allyl halide in the presence of a base, and a second step of obtaining N, by N'- dialkylated reacting 1,3-diallyl hexahydropyrimidine, 1,3-diallyl hexahydropyrimidine of N, decomposing N'- aminals site, and a third step of obtaining N, a N'- diallyl-1,3-diaminopropane, The comprising, N, N'-diallyl-1,3-diaminopropane or manufacturing method of the acid addition salts thereof.
In order to improve the reaction rate of alkali metal hydroxide or allyl chloride, in order to suppress the formation of by-products it was revealed also may be used allyl chloride. Greedy et al. Step chloride in Scheme B, N being represented by formula IIIand chloride N'- diallyl-1,3-diaminopropane, N of the formula IVN'- diallyl -1 a step of obtaining an acid addition salt of 3-diaminopropane.